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Doctor's Best Three Defenders Mushroom Complex contains beta-D-glucans from an organic trio of mushrooms - Lion's Mane, Reishi and Shiitake. Mushrooms are powerhouses from the Fungi Kingdom with nutritional and health benefits for thousands of years. Ancient royalty has sought mushrooms for longevity, circulation, cognition, digestion, nerve, liver, and oxidants with immunostimulatory effects to optimize the immune system.